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pentobarbital will lower the level or effect of brexpiprazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. Double brexpiprazole dose over 1-two months if administered with a powerful CYP3A4 inducer.pentobarbital will minimize the extent or effect of zolpidem by affecting hepatic/intestinal enzyme CYP3A4